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In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent. Expression of co-receptor (CD4 or CD8) and its binding to MHC is also required for positive selection; mice expressing a defective CD4 that cannot bind. ZAP expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study.

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CD4 is a co-receptor which participates in signaling through the T cell receptor by making contacts with MHC class II expressed on antigen-presenting cells (APC). ZAP expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent.

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Download scientific diagram | CD4 expression increases after T cell activation independently of the stimulus used to activate CD4 T cells. CD4 is a co-receptor which participates in signaling through the T cell receptor by making contacts with MHC class II expressed on antigen-presenting cells (APC). ZAP expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study.